Abstract | CONTEXT: OBJECTIVE: DESIGN: Randomized, prospective, double-blind clinical trial. SETTING: Brigham and Women's Hospital. PATIENTS: MAIN OUTCOME MEASURES: The rate of DVT detected by venous ultrasonography prior to hospital discharge. RESULTS: Symptomatic DVT or PE developed in none of the patients. The overall rate of asymptomatic VTE was 9.3%, with no significant difference in the rates between the two prophylaxis groups. Ten of the 14 patients identified with VTE had thrombus limited to the deep veins of the calf. CONCLUSIONS:
Enoxaparin, 40 mg/d, or unfractionated heparin, 5,000 U bid, in combination with graduated compression stockings, intermittent pneumatic compression, and predischarge surveillance venous ultrasonography of the legs, resulted in 150 consecutive patients without symptomatic VTE. The low 9.3% frequency of asymptomatic VTE comprised mostly isolated calf DVT. Therefore, this comprehensive, multimodality approach to VTE prophylaxis achieved excellent efficacy and safety.
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Authors | Samuel Z Goldhaber, Kelly Dunn, Marie Gerhard-Herman, John K Park, Peter McL Black |
Journal | Chest
(Chest)
Vol. 122
Issue 6
Pg. 1933-7
(Dec 2002)
ISSN: 0012-3692 [Print] United States |
PMID | 12475829
(Publication Type: Clinical Trial, Comparative Study, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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Chemical References |
- Enoxaparin
- Fibrinolytic Agents
- Heparin
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Topics |
- Bandages
- Brain Neoplasms
(surgery)
- Combined Modality Therapy
- Craniotomy
- Double-Blind Method
- Enoxaparin
(administration & dosage)
- Female
- Fibrinolytic Agents
(administration & dosage)
- Gravity Suits
- Heparin
(administration & dosage)
- Humans
- Male
- Postoperative Complications
(prevention & control)
- Prospective Studies
- Thromboembolism
(etiology, prevention & control)
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