Abstract | OBJECTIVE: To establish epidemiological, clinical and laboratory differences between adult patients with proven acute human granulocytic ehrlichiosis (HGE) and patients with the initial phase of tick-borne encephalitis (TBE). METHODS: Epidemiological, clinical and laboratory findings were compared in nine patients with acute HGE (established by the presence of specific DNA sequences of Ehrlichia phagocytophila in whole blood by polymerase chain reaction and/or by seroconversion or at least a four-fold change of serum antibody titres to E. phagocytophila by indirect immunofluorescence assay) and 29 patients with the initial phase of TBE (demonstrated in ELISA tests by the presence of serum IgM antibodies to TBE virus). RESULTS: Findings were similar for the majority of the general parameters examined, which included sex, age, incubation period, duration of fever, and frequency of additional tick bites. However, a statistically significant difference was found for the duration of fever before the first visit (median 7 days in patients with acute HGE and 4 days in patients with the initial phase of TBE; p = 0.0169), and for the frequency of hospitalisation, which was higher for patients with the initial phase of TBE (29/29) than for those with acute HGE (5/9; p = 0.0017). Comparison of clinical signs and symptoms and laboratory findings in the two groups revealed significant differences: in patients with acute HGE there was a higher frequency of chills (4/9 versus 3/29, respectively; p = 0.0407), myalgia (8/9 versus 13/29, respectively; p = 0.0263), and arthralgia (7/9 versus 3/29, respectively; p = 0.0003), and elevated values of lactate dehydrogenase (7/9 versus 3/29, respectively; p = 0.0003) and concentration of C-reactive protein (9/9 versus 6/29, respectively; p = 0.0000). CONCLUSIONS:
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Authors | Stanka Lotric-Furlan, Miroslav Petrovec, Tatjana Avsic-Zupanc, Mateja Logar, Franc Strle |
Journal | Wiener klinische Wochenschrift
(Wien Klin Wochenschr)
Vol. 114
Issue 13-14
Pg. 636-40
(Jul 31 2002)
ISSN: 0043-5325 [Print] Austria |
PMID | 12422617
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Topics |
- Adult
- Aged
- Aged, 80 and over
- Anaplasma phagocytophilum
(genetics)
- Animals
- Bites and Stings
(complications)
- Cross-Sectional Studies
- Diagnosis, Differential
- Ehrlichiosis
(diagnosis, epidemiology, immunology)
- Encephalitis, Tick-Borne
(diagnosis, epidemiology, immunology)
- Enzyme-Linked Immunosorbent Assay
- Humans
- Middle Aged
- Patient Admission
(statistics & numerical data)
- Polymerase Chain Reaction
- Serologic Tests
- Slovenia
- Ticks
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