Abstract | BACKGROUND/AIMS: Rats with mild hyperuricemia develop systemic hypertension, interstitial renal disease, afferent arteriolopathy, and increased renin expression [Mazzali et al.: Am J Physiol 2002;6:F991-F997]. We hypothesized that hyperuricemia might also induce glomerular changes. METHODS: RESULTS: Renal biopsies showed that hyperuricemic rats had a 30% increase in glomerular tuft area (p < 0.01); these changes were prevented by allopurinol and benziodarone. Control of blood pressure with hydrochlorothiazide did not prevent the development of glomerular hypertrophy, whereas enalapril partially reduced the glomerular hypertrophy. Prolonged hyperuricemia was associated with the development of microalbuminuria (p < 0.05) and glomerulosclerosis (22 vs. 10%, p < 0.05) compared to control rats. CONCLUSIONS:
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Authors | Takahiko Nakagawa, Marilda Mazzali, Duk-Hee Kang, John Kanellis, Susumu Watanabe, Laura G Sanchez-Lozada, Bernardo Rodriguez-Iturbe, Jaime Herrera-Acosta, Richard J Johnson |
Journal | American journal of nephrology
(Am J Nephrol)
2003 Jan-Feb
Vol. 23
Issue 1
Pg. 2-7
ISSN: 0250-8095 [Print] Switzerland |
PMID | 12373074
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)
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Copyright | Copyright 2003 S. Karger AG, Basel |
Topics |
- Animals
- Hypertrophy
- Hyperuricemia
(complications)
- Kidney Glomerulus
(pathology)
- Male
- Rats
- Rats, Sprague-Dawley
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