Abstract |
Metallothionein (MT) expression is observed in various carcinomas, but its role is not fully understood. To clarify the clinicopathological significance of MT, 87 colorectal adenomas and 128 early-stage carcinomas were immunohistochemically analysed for MT expression. The degree of MT immunostaining of a specimen was graded according to the proportion of MT-positive cells; negative (<5%) and positive (focally 5-50%, diffusely >50%). MT expression significantly decreased with tumour development. For carcinomas, MT-positivity was significantly associated with depth of invasion (T1 60% versus T2 33%; P<0.01), vascular involvement (positive 35% versus negative 61%; P<0.01) and morphology (polypoid 62% versus depressed 26%; P<0.01). Regarding MT-positive distribution, the diffuse-positive rate in MT-positive polypoid lesions was 28%, while MT-positive depressed lesions were all diffusely stained (P<0.01). In conclusion, our results suggested that decreasing MT expression is an early event in colorectal carcinogenesis and may reflect local invasion. Furthermore, MT-positive distribution may reflect genetic differences between the polypoid and depressed-type.
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Authors | K Kuroda, N Aoyama, T Tamura, M Sakashita, S Maekawa, T Inoue, C Wambura, D Shirasaka, R Minami, S Maeda, Y Kuroda, M Kasuga |
Journal | European journal of cancer (Oxford, England : 1990)
(Eur J Cancer)
Vol. 38
Issue 14
Pg. 1879-87
(Sep 2002)
ISSN: 0959-8049 [Print] England |
PMID | 12204670
(Publication Type: Journal Article)
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Chemical References |
- Neoplasm Proteins
- Proliferating Cell Nuclear Antigen
- Metallothionein
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Topics |
- Adult
- Aged
- Aged, 80 and over
- Colonic Polyps
(metabolism)
- Colorectal Neoplasms
(metabolism)
- Female
- Humans
- Immunohistochemistry
(methods)
- Intestinal Mucosa
(metabolism)
- Male
- Metallothionein
(metabolism)
- Middle Aged
- Neoplasm Proteins
(metabolism)
- Proliferating Cell Nuclear Antigen
(metabolism)
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