The effects of benzodiazepines on event-related potential indices of automatic and controlled processing in schizophrenia: a preliminary report.

Abstract

The effects of benzodiazepines on cognitive function in schizophrenic patients were investigated using event-related potential (ERP) measurement during an auditory selective attention task. In this study, the authors compared the mismatch negativity (MMN) and N2b components between two subgroups of schizophrenic patients: one is comprised of patients who received no benzodiazepines (NT group, n = 7) and the other is comprised of those administered benzodiazepines in the daytime (T group, n = 7). There were no significant differences in MMN and N2b amplitudes between the two subgroups, whereas the N2b latency was significantly prolonged in the T group relative to the NT group. This suggested that benzodiazepines induce delayed stimulus classification processing in schizophrenic patients.

• Authors: Tadashi Murakami, Kazuyuki Nakagome, Satoru Kamio, Kiyoto Kasai, Akira Iwanami, Ken-Ichi Hiramatsu, Masato Fukuda, Akinobu Hata, Makoto Honda, Akira Watanabe, Nobumasa Kato
• Journal: Progress in neuro-psychopharmacology & biological psychiatry (Prog Neuropsychopharmacol Biol Psychiatry) Vol. 26 Issue 4 Pg. 651-61 (May 2002) ISSN: 0278-5846 [Print] England
• PMID: 12188096 (Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Benzodiazepines

Topics

• Adolescent
• Adult
• Analysis of Variance
• Attention (drug effects, physiology)
• Benzodiazepines (pharmacology, therapeutic use)
• Cognition (drug effects, physiology)
• Evoked Potentials (drug effects, physiology)
• Evoked Potentials, Auditory (drug effects, physiology)
• Female
• Humans
• Male
• Schizophrenia (drug therapy, physiopathology)
• Statistics, Nonparametric