Abstract | BACKGROUND: OBJECTIVE: Our aim was to study eosinophil and neutrophil involvement in CSS. METHODS: RESULTS: Indirect immunofluorescence showed prominent cellular and extracellular staining for EDN in skin biopsy specimens; MBP staining was less extensive. Five biopsy specimens showed marked cellular NE staining; 4 showed prominent extracellular NE. Serum and blister fluid specimens contained elevated MBP, EDN, and interleukin 5 levels and enhanced eosinophil survival in culture. Granulocyte-macrophage colony-stimulating factor and interleukin 5 were detected in blister fluid. Blister fluid contained more NE than normal serum. CONCLUSIONS: Both eosinophils and neutrophils likely participate in skin lesion development in CSS.
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Authors | Lisa A Drage, Mark D P Davis, Fernando De Castro, Virginia Van Keulen, Ellen A Weiss, Gerald J Gleich, Kristin M Leiferman |
Journal | Journal of the American Academy of Dermatology
(J Am Acad Dermatol)
Vol. 47
Issue 2
Pg. 209-16
(Aug 2002)
ISSN: 0190-9622 [Print] United States |
PMID | 12140466
(Publication Type: Case Reports, Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)
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Topics |
- Adult
- Churg-Strauss Syndrome
(immunology, metabolism, physiopathology)
- Eosinophils
(physiology)
- Female
- Fluorescent Antibody Technique, Indirect
- Humans
- Immunohistochemistry
- Male
- Middle Aged
- Neutrophils
(physiology)
- Skin
(metabolism)
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