Abstract |
Venous thromboembolism (VTE) is one of the common manifestations in the anti- phospholipid (aPL) syndrome. We examined the levels of IgG antibodies (Abs) to beta2-glycoprotein I (beta2-GP I) and prothrombin, lupus anticoagulant (LA) activity, activated protein C resistance (APC-R), and factor V Leiden in 96 patients with systemic lupus erythematosus (SLE); 19 with VTE and 77 without VTE. Acquired APC-R, which was not found in any patient with the factor V Leiden mutation, was present in 33 (34.4%) out of the 96 patients with SLE. The presence of acquired APC-R was a strong risk factor for VTE. The SLE patients were divided into four groups according to the results of enzyme-linked immunosorbent assay (ELISA) and LA activity for each aPL Abs: ELISA+, LA+; ELISA+, LA-; ELISA-, LA+; and ELISA-, LA-. A significant association was observed between APC-R and the co-existence of anti-beta2-GP I Abs and LA activity or of anti- prothrombin Abs and LA activity. There was no association between APC-R and the presence of anti-beta2-GP I Abs, anti- prothrombin Abs, or LA activity alone. However, when multivariate logistical regression analysis was performed, it was clear that only the co-existence of anti- prothrombin and LA activity was a significant risk factor for APC-R. These findings indicate that the co-existence of anti- prothrombin Abs and LA activity may be an important factor in the pathogenesis of acquired APC-R in patients with SLE.
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Authors | Junzo Nojima, Hirohiko Kuratsune, Etsuji Suehisa, Tomio Kawasaki, Takashi Machii, Teruo Kitani, Yoshinori Iwatani, Yuzuru Kanakura |
Journal | British journal of haematology
(Br J Haematol)
Vol. 118
Issue 2
Pg. 577-83
(Aug 2002)
ISSN: 0007-1048 [Print] England |
PMID | 12139749
(Publication Type: Journal Article)
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Chemical References |
- Antibodies, Antiphospholipid
- Glycoproteins
- Immunoglobulin G
- Lupus Coagulation Inhibitor
- beta 2-Glycoprotein I
- factor V Leiden
- Factor V
- Prothrombin
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Topics |
- Activated Protein C Resistance
(etiology)
- Adult
- Aged
- Antibodies, Antiphospholipid
(analysis)
- Enzyme-Linked Immunosorbent Assay
(methods)
- Factor V
- Female
- Glycoproteins
(immunology)
- Humans
- Immunoglobulin G
(metabolism)
- Lupus Coagulation Inhibitor
(physiology)
- Lupus Erythematosus, Systemic
(complications)
- Male
- Middle Aged
- Prothrombin
(immunology)
- Risk Factors
- Thromboembolism
(etiology)
- Venous Thrombosis
(etiology)
- beta 2-Glycoprotein I
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