[Contribution of delta1-opioid receptors in regulation of cardiac resistance to ischemia-reperfusion].

Abstract

It has been found that pretreatment with a delta 1-opioid receptor agonist, DPDPE, in dose of 0.1 mg/kg intravenously 15 min before heart isolation, prevents appearance of reperfusion, ventricular arrhythmias during total global ischemia (45 min) and reperfusion (10 min) of isolated rat heart. This effect was dose-dependent. Addition of DPDPE to the perfusion solution in a final concentration of 0.1 mg/L and/or 0.5 mg/L 15 min before ischemia also decreased the incidence of reperfusion arrhythmias in a concentration-dependent manner. Addition of DPDPE to the perfusion solution in a final concentration of 0.1 mg/L also decreased creatine kinase levels in the coronary sinus. However DPDPE had no cardio-protective effect in concentration of 0.5 mg/L or after intravenous administration. A previous intravenous injection of DPDPE in dose of 0.5 mg/kg exacerbated reperfusion-induced contractile dysfunction of isolated heart but exerted no effect in dose of 0.1 mg/kg. Previous perfusion of the rat isolated heart by DPDPE in concentration of 0.1 mg/L and 0.5 mg/L 15 min before ischemia also exacerbated myocardial contractile dysfunction during reperfusion. It is proposed that the antiarrhythmic, cardio-protective and negative inotropic effect of DPDPE during reperfusion may be due to stimulation of cardiac delta-1 receptors.

• Authors: T V Lasukova, L N Maslov, Iu B Lishmanov, G L Gross
• Journal: Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova (Ross Fiziol Zh Im I M Sechenova) Vol. 88 Issue 5 Pg. 568-80 (May 2002) ISSN: 0869-8139 [Print] Russia (Federation)
• Vernacular Title: Vklad delta1-opiatnykh retseptorov v reguliatsiiu ustoĭchivosti izolirovannogo serdtsa k vozdeĭstviiu ishemii-reperfuzii.
• PMID: 12136724 (Publication Type: English Abstract, Journal Article)

Chemical References

• Anti-Arrhythmia Agents
• Receptors, Opioid, delta
• Enkephalin, D-Penicillamine (2,5)-

Topics

• Animals
• Anti-Arrhythmia Agents (pharmacology)
• Arrhythmias, Cardiac (etiology, prevention & control)
• Dose-Response Relationship, Drug
• Enkephalin, D-Penicillamine (2,5)- (pharmacology)
• Male
• Myocardial Ischemia (complications)
• Myocardial Reperfusion Injury (etiology, prevention & control)
• Rats
• Rats, Wistar
• Receptors, Opioid, delta (agonists)