Abstract | BACKGROUND: METHODS: RESULTS: The percentage of cells that stained positively with Fas in benign prostate tissue (mean, 2%) was statistically significantly lower compared with that in prostatic intraepithelial neoplasia (mean, 13%; P = 0.0014) and prostatic adenocarcinoma (mean, 31%; P = 0.0001). The staining intensity of Fas was significantly less in benign prostate tissue compared with the staining intensity in PIN and prostatic adenocarcinoma. The percentage of cells that stained positively with Fas ligand in benign prostate tissue (mean, 13%) was statistically significantly lower compared with that in PIN (mean, 47%; P = 0.0001) and in prostatic adenocarcinoma (mean, 53%; P = 0.0001). The staining intensity of Fas ligand was significantly less in benign prostate tissue compared with that in PIN and prostatic adenocarcinoma. CONCLUSIONS: Data from the current study indicate that Fas/ Fas ligand is elevated in prostatic malignancy, suggesting that Fas-mediated apoptosis may be a potential target for therapeutic intervention.
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Authors | Jiazhong Jiang, Thomas M Ulbright, Shaobo Zhang, George J Eckert, Chinghai Kao, Thomas A Gardner, Michael O Koch, John N Eble, Liang Cheng |
Journal | Cancer
(Cancer)
Vol. 95
Issue 2
Pg. 296-300
(Jul 15 2002)
ISSN: 0008-543X [Print] United States |
PMID | 12124829
(Publication Type: Journal Article)
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Copyright | Copyright 2002 American Cancer Society.DOI 10.1002/cncr.10674 |
Chemical References |
- FASLG protein, human
- Fas Ligand Protein
- Ligands
- Membrane Glycoproteins
- fas Receptor
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Topics |
- Adenocarcinoma
(metabolism, pathology)
- Aged
- Apoptosis
- Fas Ligand Protein
- Humans
- Immunohistochemistry
- Ligands
- Male
- Membrane Glycoproteins
(analysis)
- Middle Aged
- Prostatic Intraepithelial Neoplasia
(metabolism, pathology)
- Prostatic Neoplasms
(metabolism, pathology)
- fas Receptor
(analysis)
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