A rhesus monkey model of respiratory syncytial virus infection.

Abstract

Respiratory syncytial virus (RSV) is a major cause of lower respiratory tract disease in infants and young children worldwide. To date, there is no single animal model that adequately reproduces all human disease states. Here, we have developed a model of experimental infection with human RSV in infant Rhesus macaques. Infected animals demonstrated mild clinical disease including increased respiratory rates, fever and adventitious lung sounds. While more severe disease was not observed, preliminary virological and histopathological findings are promising. It is anticipated that with further optimization, this model will provide a useful system with which to study disease due to RSV infection and evaluate candidate vaccines.

• Authors: K McArthur-Vaughan, L J Gershwin
• Journal: Journal of medical primatology (J Med Primatol) Vol. 31 Issue 2 Pg. 61-73 (Apr 2002) ISSN: 0047-2565 [Print] Denmark
• PMID: 12110049 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)

Topics

• Animals
• Animals, Newborn
• Child
• Child, Preschool
• Disease Models, Animal
• Fever (etiology)
• Humans
• Infant
• Infant, Newborn
• Macaca mulatta
• Respiration
• Respiratory Syncytial Virus Infections (pathology, veterinary)
• Respiratory Syncytial Viruses (pathogenicity)