Abstract |
Preoperative or postoperative pelvic radiation plus concurrent fluorouracil-based chemotherapy is standard adjuvant treatment for patients with T3 and/or N1/2 rectal cancer. Newer chemotherapeutic regimens have been developed for the treatment of patients with metastatic disease. Irinotecan (CPT-11, Camptosar)-based regimens have improved survival in patients with metastatic disease and are being actively investigated in combination with pelvic radiation therapy for patients with rectal cancer.
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Authors | Bruce D Minsky |
Journal | Oncology (Williston Park, N.Y.)
(Oncology (Williston Park))
Vol. 16
Issue 5 Suppl 5
Pg. 35-8
(May 2002)
ISSN: 0890-9091 [Print] United States |
PMID | 12109805
(Publication Type: Journal Article, Review)
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Chemical References |
- Irinotecan
- Fluorouracil
- Camptothecin
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Topics |
- Adenocarcinoma
(drug therapy, pathology, radiotherapy)
- Antineoplastic Combined Chemotherapy Protocols
(therapeutic use)
- Camptothecin
(administration & dosage, analogs & derivatives)
- Clinical Trials as Topic
- Combined Modality Therapy
- Fluorouracil
(administration & dosage)
- Humans
- Irinotecan
- Preoperative Care
- Radiotherapy, Adjuvant
- Rectal Neoplasms
(drug therapy, pathology, radiotherapy)
- Treatment Outcome
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