A 588-gene microarray analysis of the peripheral blood mononuclear cells of spondyloarthropathy patients.
Abstract | OBJECTIVES: METHODS: A 588-gene microarray was used as a screening tool to select a panel of such genes from PBMC of these subjects and of normal subjects. Results were then validated by reverse transcription-polymerase chain reaction (RT-PCR). RESULTS: CONCLUSIONS: The CXCR4/SDF-1 is a potential pro-inflammatory axis for RA, PsA and SpA.
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Authors | J Gu, E Märker-Hermann, D Baeten, W C Tsai, D Gladman, M Xiong, H Deister, J G Kuipers, F Huang, Y W Song, W Maksymowych, J Kalsi, M Bannai, N Seta, M Rihl, L J Crofford, E Veys, F De Keyser, D T Y Yu |
Journal | Rheumatology (Oxford, England)
(Rheumatology (Oxford))
Vol. 41
Issue 7
Pg. 759-66
(Jul 2002)
ISSN: 1462-0324 [Print] England |
PMID | 12096225
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Antigens, Differentiation
- CXCL12 protein, human
- Chemokine CXCL12
- Chemokines, CXC
- Genetic Markers
- Receptors, CXCR4
- DNA
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Topics |
- Adolescent
- Adult
- Aged
- Antigens, Differentiation
(blood, genetics)
- Arthritis, Psoriatic
(blood, genetics)
- Arthritis, Rheumatoid
(blood, genetics)
- Chemokine CXCL12
- Chemokines, CXC
(blood, genetics)
- DNA
(analysis)
- Female
- Genetic Markers
- Humans
- Leukocytes, Mononuclear
(metabolism)
- Male
- Middle Aged
- Oligonucleotide Array Sequence Analysis
- Receptors, CXCR4
(blood, genetics)
- Reverse Transcriptase Polymerase Chain Reaction
- Spondylitis, Ankylosing
(blood, genetics, pathology)
- Synovial Membrane
(metabolism, pathology)
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