Effects of angiotensin II infusion on renal excretion of purine bases and oxypurinol.
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| Abstract |
The effect of angiotensin II infusion on the renal transport of purine bases and oxypurinol (a metabolite of allopurinol) was investigated in 5 healthy subjects who were orally given allopurinol (300 mg) 9 hours prior to the study. Angiotensin II was intravenously administered at 8 ng/min/kg for 2 hours. The fractional clearances of uric acid, xanthine, and oxypurinol were significantly decreased during angiotensin II infusion; however, that of hypoxanthine did not change. The urinary excretion levels of uric acid, xanthine, and oxypurinol were also significantly decreased during angiotensin II infusion. These results suggest that angiotensin II infusion affected the renal clearances of uric acid, xanthine, and oxypurinol through direct tubular transport and/or hemodynamic changes. Accordingly, the hypouricemic effect of allopurinol may be exaggerated in hypertensive gout patients with an enhanced renin-angiotensin system, since an increased biological half-life of oxypurinol is expected in these patients.
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| Authors | Yuji Moriwaki, Tetsuya Yamamoto, Zenta Tsutsumi, Sumio Takahashi, Toshikazu Hada |
| Journal | Metabolism: clinical and experimental (Metabolism) Vol. 51 Issue 7 Pg. 893-5 (Jul 2002) ISSN: 0026-0495 [Print] United States |
| PMID | 12077737 (Publication Type: Clinical Trial, Journal Article) |
| Copyright | Copyright 2002, Elsevier Science (USA). All rights reserved. |
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