Cerebrovascular disorders and genetic polymorphisms: mitochondrial DNA5178C is predominant in cerebrovascular disorders.

Abstract

We studied polymorphisms of mitochondrial DNA 5178cytosine/adenine (mt5178C/A) and angiotensin I-converting enzyme (ACE) genes (DCP1) in 127 cerebrovascular disorder (CVD) patients and 294 age-matched normal controls to clarify the genetic background of Japanese patients with CVD. Mt5178C was predominant in CVD patients compared with controls (P<0.01). The frequency of DCP1 insertion (I) and deletion (D) alleles showed no significant difference between the CVD patients and controls or between each CVD subgroup. Although the number of CVD patients in the present study was too small to make a final conclusion, mt5178C might be one of the genetic factors to be considered in Japanese patients with CVD.

• Authors: Ryuichi Ohkubo, Masanori Nakagawa, Ken-ichi Ikeda, Tomoko Kodama, Kimiyoshi Arimura, Suminori Akiba, Minoru Saito, Yosuke Ookatsu, Yoshihiko Atsuchi, Yoshihisa Yamano, Mitsuhiro Osame
• Journal: Journal of the neurological sciences (J Neurol Sci) Vol. 198 Issue 1-2 Pg. 31-5 (Jun 15 2002) ISSN: 0022-510X [Print] Netherlands
• PMID: 12039661 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• DNA, Mitochondrial
• Peptidyl-Dipeptidase A

Topics

• Aged
• Aged, 80 and over
• Asian People (genetics)
• Cerebrovascular Disorders (etiology, genetics)
• DNA, Mitochondrial (genetics)
• Female
• Gene Frequency
• Humans
• Japan
• Male
• Middle Aged
• Peptidyl-Dipeptidase A (genetics)
• Polymorphism, Genetic
• Reference Values
• Risk Factors