Chemical constituents of Calophyllum brasiliensis: structure elucidation of seven new xanthones and their cancer chemopreventive activity.

Abstract

The first study of chemical constituents of the stem bark of Calophyllum brasilienses collected in Brazil has led to the isolation and identification of seven new xanthones named brasixanthones A (1), B (4), C (5), D (6), E (2), F (3), and G (10), together with 10 known xanthones. Among the xanthones isolated in this study, 4, 5, 6, and 11 were found to exhibit significant inhibitory activity against 12-O-tetradecanoylphorbol-13-acetate induced Epstein-Barr virus early antigen activation in Raji cells.

• Authors: Chihiro Ito, Masataka Itoigawa, Yoshitaka Mishina, Valdir Cechinel Filho, Teruo Mukainaka, Harukuni Tokuda, Hoyoku Nishino, Hiroshi Furukawa
• Journal: Journal of natural products (J Nat Prod) Vol. 65 Issue 3 Pg. 267-72 (Mar 2002) ISSN: 0163-3864 [Print] United States
• PMID: 11908963 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• 1,6-dihydroxy-6',6'-dimethylpyrano(2',3':2,3)-6'',6''-dimethylpyrano(2'',3'':7,8)xanthone
• 8-desooxygartanin
• Antigens, Viral
• Antiviral Agents
• Epstein-Barr virus early antigen
• Pyrans
• Xanthenes
• Xanthones
• brasixanthone C
• brasixanthone D
• Tetradecanoylphorbol Acetate

Topics

• Antigens, Viral (drug effects)
• Antiviral Agents (chemistry, isolation & purification, pharmacology)
• Brazil
• Calophyllum (chemistry)
• Drug Screening Assays, Antitumor
• Humans
• Lymphoma, B-Cell
• Nuclear Magnetic Resonance, Biomolecular
• Plant Bark (chemistry)
• Plant Stems (chemistry)
• Plants, Medicinal (chemistry)
• Pyrans (chemistry, isolation & purification, pharmacology)
• Tetradecanoylphorbol Acetate (pharmacology)
• Tumor Cells, Cultured (drug effects)
• Xanthenes (chemistry, isolation & purification, pharmacology)
• Xanthones