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Xanthones

A group of XANTHENES that contain a 9-keto OXYGEN.
Also Known As:
Xanthone Derivatives; Derivatives, Xanthone
Networked: 211 relevant articles (8 outcomes, 33 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1. Joubert, Elizabeth: 7 articles (04/2021 - 01/2011)
2. Mah, Siau Hui: 5 articles (01/2021 - 02/2013)
3. Li, Xiang: 5 articles (10/2017 - 11/2012)
4. Marona, Henryk: 4 articles (10/2021 - 01/2013)
5. Szkaradek, Natalia: 4 articles (10/2021 - 01/2013)
6. Pinto, Madalena: 4 articles (06/2021 - 12/2002)
7. Zuo, Jian: 4 articles (01/2021 - 06/2014)
8. Shen, Rui: 4 articles (10/2020 - 11/2010)
9. Teh, Soek Sin: 4 articles (01/2020 - 02/2013)
10. de Beer, Dalene: 4 articles (11/2019 - 10/2014)

Related Diseases

1. Neoplasms (Cancer)
08/13/2013 - "This review will (a) critically address recent reports of in vivo studies on the bioavailability and metabolism of mangosteen xanthones, (b) update the in vitro and in vivo data on anti-cancer and anti-inflammatory activities of mangosteen xanthones, and (c) suggest needed areas of inquiry regarding the absorption, metabolism and efficacy of mangosteen xanthones. "
08/03/2023 - "aureus, while the isolated compounds 7-9 showed good antibacterial activity, with IC50 values of 0.56 to 17.33 µg/mL. The EtOH extract displayed selective cytotoxicity against the A-549 cancer cell line, with IC50 values of 22.82 ± 0.86 µg/mL, and the xanthones 8 and 9 exhibited good activity against the KB, HepG-2, and A-549 cancer cell lines, with IC50 values ranging from 7.55 ± 0.25 µg/mL to 29.27 ± 2.07 µg/mL. The cytotoxic effects of xanthones 8 and 9 were determined by the inhibition of the EGFR and HER2 pathways using a molecular docking study. "
01/01/2023 - "Further clinical studies with conclusive results are required to implement xanthones as treatment modalities in cancer."
01/01/2018 - "In this study, a structure-activity relationship (SAR) of caged xanthones and their derivatives for anticancer activity against different cancer cell lines such as A549, HepG2 and U251 were developed through quantitative (Q)-SAR modeling approach. "
06/16/2017 - "Synthesis of xanthone derivatives and studies on the inhibition against cancer cells growth and synergistic combinations of them."
2. Chronic Renal Insufficiency
3. Arthritis (Polyarthritis)
4. Colorectal Neoplasms (Colorectal Cancer)
5. Myocardial Ischemia (Ischemic Heart Diseases)

Related Drugs and Biologics

1. lead acetate
2. Nitric Oxide Synthase (NO Synthase)
3. xanthone
4. Flavonoids
5. Antioxidants
6. mangostin
7. Benzophenones
8. Phytochemicals
9. Terpenes (Terpenoids)
10. Coumarins

Related Therapies and Procedures

1. Therapeutics
2. Traditional Medicine (Folk Remedies)
3. Chemoprevention
4. Intravenous Injections
5. Drug Therapy (Chemotherapy)