Effects of SM-20550, a new Na(+)/H(+) exchange inhibitor, on survival and infarct size in rat myocardial infarction.

Abstract

The effect of a novel potent Na(+)/H(+) exchange inhibitor, SM-20550 [N-(aminoiminomethyl)-1,4-dimethyl-1H-indole-2-carboxamide methanesulfonic acid], on survival after myocardial infarction was studied. Anesthetized rats underwent occlusion of the coronary artery (30 min) followed by reperfusion (14 days). SM-20550 was administered intravenously before ischemia (1-day treatment group) or before ischemia and on the 2 days following (3-day treatment group). The infarct size was significantly reduced on the 14th day after surgery by approximately 17 and 20% in 1- and 3-day treatment groups, respectively. The survival rate on day 14 was significantly enhanced in both treatment groups (96%) compared with the vehicle-treated control group (70%). These results suggest that SM-20550 improved survival after myocardial infarction, at least due to its antinecrotic effect.

• Authors: Kazuto Yamada, Masao Sasabe, Kazuki Matsui, Setsuko Yamamoto, Naohito Ohashi
• Journal: Pharmacology (Pharmacology) Vol. 64 Issue 4 Pg. 176-81 (Apr 2002) ISSN: 0031-7012 [Print] Switzerland
• PMID: 11893897 (Publication Type: Journal Article)
• Copyright: Copyright 2002 S. Karger AG, Basel

Chemical References

• Amidines
• Indoles
• SM 20550
• Sodium-Hydrogen Exchangers

Topics

• Amidines (pharmacology)
• Animals
• Indoles (pharmacology)
• Male
• Myocardial Infarction (mortality, pathology, prevention & control)
• Myocardium (pathology)
• Organ Size (drug effects)
• Rats
• Rats, Wistar
• Severity of Illness Index
• Sodium-Hydrogen Exchangers (antagonists & inhibitors)
• Survival Rate
• Time Factors