Chemokine receptor polymorphism and risk of acute rejection in human renal transplantation.
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| Abstract |
Chemokines regulate the trafficking of leukocytes in immunity and inflammation and have been implicated in mouse models in acute cardiac and renal allograft rejection; however, their significance to human transplantation is not yet defined. The association of human chemokine receptor genetic variants, CCR5-Delta32, CCR5-59029-A/G, CCR2-V64I, CX3CR1-V249I, and CX3CR1-T280M, with outcome in 163 renal transplant recipients was examined here. Significant reductions were found in risk of acute renal transplant rejection in recipients who possessed the CCR2-64I allele (odds ratio [OR], 0.30; 95% confidence interval [CI], 0.12 to 0.78; P = 0.014) or who were homozygous for the 59029-A allele (OR, 0.37; 95% CI, 0.16 to 0.85; P = 0.016). There were no significant differences in the incidence of rejection among patients stratified as with or without CCR5-Delta32 or by the CX3CR1-V249I or CX3CR1-T280M genotypes. Adjustment for known risk factors for transplant rejection confirmed the univariate findings for possession of the CCR2-64I allele (OR, 0.20; P = 0.032) and homozygosity for the 59029-A allele (OR, 0.26; P = 0.027). It was concluded that the risk of acute rejection in renal transplantation is associated with genetic variation in the chemokine receptors CCR2 and CCR5.
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| Authors | Reza Abdi, Tran Thi Bich Huong, Alfredo Sahagun-Ruiz, Philip M Murphy, Barry M Brenner, Edgar L Milford, David H McDermott |
| Journal | Journal of the American Society of Nephrology : JASN (J Am Soc Nephrol) Vol. 13 Issue 3 Pg. 754-758 (Mar 2002) ISSN: 1046-6673 [Print] United States |
| PMID | 11856781 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't) |
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