Controversy in multiple myeloma transplants: tandem autotransplants and mini-allografts.

Abstract

Autologous stem cell transplantation appears to enhance outcome in multiple myeloma patients. To improve upon these results, various groups have utilized tandem autografts, as well as used reduced-conditioning allogeneic stem cell transplantation. These two approaches, discussed herein, have been promising. Inherent patient selection, however, appears to play a role and much of the data have not yet been subjected to peer-review scrutiny. At present, these strategies remain investigational and cannot be considered the standard-of-care for multiple myeloma patients.

• Authors: D H Vesole, A Simic, H M Lazarus
• Journal: Bone marrow transplantation (Bone Marrow Transplant) Vol. 28 Issue 8 Pg. 725-35 (Oct 2001) ISSN: 0268-3369 [Print] England
• PMID: 11781623 (Publication Type: Journal Article, Review)

Topics

• Adult
• Antineoplastic Combined Chemotherapy Protocols (therapeutic use)
• Clinical Trials as Topic
• Combined Modality Therapy
• Graft vs Host Disease (etiology)
• Hematopoietic Stem Cell Mobilization (methods)
• Hematopoietic Stem Cell Transplantation (methods)
• Humans
• Middle Aged
• Multiple Myeloma (drug therapy, mortality, therapy)
• Prognosis
• Prospective Studies
• Randomized Controlled Trials as Topic
• Remission Induction
• Risk Factors
• Transplantation Conditioning (adverse effects, methods)
• Transplantation, Autologous
• Transplantation, Homologous
• Treatment Outcome