Histometric evaluation of the effect of nicotine administration on periodontal breakdown: an in vivo study.
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| Abstract |
The present study investigated the effect of nicotine administration on periodontal breakdown resulting from ligature-induced periodontitis in rats. Twenty adult male Wistar rats were used. After anesthesia, a mandibular first molar was randomly assigned to receive a cotton ligature in the sulcular area while the contralateral tooth was left unligated. The animals were randomly assigned to one of the following treatments. of daily intraperitoneal injections: A - saline solution, B -0.37 mg of nicotine kg, C -0.57 mg of nicotine kg and D -0.73 mg of nicotine/kg. Thirty days later, the animals were sacrificed and the specimens routinely processed for serial decalcified sections. Statistical analysis (ANOVA) revealed greater bone loss (p<0.05) in the ligated teeth of animals which received nicotine (groups B/C D) than in the ligated teeth of animals which received saline solution (group A). In addition, a dose-dependent response was observed among the nicotine groups. A negative effect of nicotine was observed in the unligated teeth of the experimental groups (p<0.05). Therefore, daily administration of nicotine enhanced, in a dose-dependent manner, the effects of local factors in producing periodontal breakdown. Furthermore, the nicotine seemed to have a direct deleterious effect on the periodontal tissues.
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| Authors | F H Nociti Jr, G R Nogueira-Filho, V A Tramontina, M A Machado, S P Barros, E A Sallum, A W Sallum |
| Journal | Journal of periodontal research (J Periodontal Res) Vol. 36 Issue 6 Pg. 361-6 (Dec 2001) ISSN: 0022-3484 [Print] United States |
| PMID | 11762871 (Publication Type: Journal Article) |
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