Immunity to placental malaria. III. Impairment of interleukin(IL)-12, not IL-18, and interferon-inducible protein-10 responses in the placental intervillous blood of human immunodeficiency virus/malaria-coinfected women.

Abstract

Pregnant women are highly susceptible to malaria, and human immunodeficiency virus (HIV) infection increases this susceptibility. In our previous studies, placental malaria (PM), HIV infection, and HIV/PM coinfection were all associated with decreased interferon (IFN)-gamma production by maternal placental (intervillous) blood mononuclear cells (IVBMC). This study investigated whether in vitro production of the IFN-gamma regulatory cytokines interleukin (IL)-12 and IL-18 and the chemokine IFN-inducible protein (IP)-10 by IVBMC is altered in women who have been exposed to malaria and are infected with HIV. IL-12 production from IVBMC was significantly lower in HIV-positive women, regardless of PM status, in contrast to HIV-negative, PM-negative women. IL-18 and IP-10 production by IVBMC was reduced in HIV-positive, PM-negative women but elevated in HIV-positive, PM-positive women. These results reveal a substantial impairment of IL-12 production by IVBMC in HIV-positive women, implicating this cytokine as a potentially critical regulator of malaria antigen-specific IFN-gamma responses in HIV-infected and HIV/PM-coinfected women.

• Authors: Sujittra Chaisavaneeyakorn, Julie M Moore, Juliana Otieno, Sansanee C Chaiyaroj, Douglas J Perkins, Ya Ping Shi, Bernard L Nahlen, Altaf A Lal, Venkatachalam Udhayakumar
• Journal: The Journal of infectious diseases (J Infect Dis) Vol. 185 Issue 1 Pg. 127-31 (Jan 01 2002) ISSN: 0022-1899 [Print] United States
• PMID: 11756993 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, Non-P.H.S., Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Chemokine CXCL10
• Chemokines, CXC
• Interleukin-18
• Interleukins
• Interleukin-12
• Interferon-gamma

Topics

• Chemokine CXCL10
• Chemokines, CXC (blood)
• Chorionic Villi (blood supply, immunology)
• Disease Susceptibility
• Female
• HIV Infections (complications, epidemiology, immunology)
• Humans
• Interferon-gamma (blood)
• Interleukin-12 (blood)
• Interleukin-18 (blood)
• Interleukins (blood)
• Kenya (epidemiology)
• Malaria, Falciparum (complications, epidemiology, immunology)
• Placenta (blood supply, immunology)
• Placenta Diseases (complications, epidemiology, immunology)
• Pregnancy