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Chemopreventive efficacy of selenium against N-nitrosodiethylamine-induced hepatoma in albino rats.

Abstract
The chemopreventive/chemotherapeutic effect of sodium selenite on tricarboxylic acid cycle key enzymes was investigated against hepatoma induced by environmental carcinogen N-nitrosodiethylamine. Decreased activities of TCA cycle key enzymes such as isocitrate dehydrogenase (ICDH), succinate dehydrogenase (SDH), malate dehydrogenase (MDH) and alpha-ketoglutarate dehydrogenase (alpha-KGDH) in hepatoma and surrounding tissues of hepatoma-bearing rats were observed. Upon selenium supplementation the above biochemical changes were reverted in a dose- and duration-dependent manner. This study further confirms the chemopreventive/chemotherapeutic effect of sodium selenite which is found to be more effective in the initiation phase of carcinogenesis.
AuthorsC Thirunavukkarasu, J P Singh, K Selvendiran, D Sakthisekaran
JournalCell biochemistry and function (Cell Biochem Funct) Vol. 19 Issue 4 Pg. 265-71 (Dec 2001) ISSN: 0263-6484 [Print] England
PMID11746207 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
CopyrightCopyright 2001 John Wiley & Sons, Ltd.
Chemical References
  • Alkylating Agents
  • Anticarcinogenic Agents
  • Diethylnitrosamine
  • Malate Dehydrogenase
  • Isocitrate Dehydrogenase
  • Ketoglutarate Dehydrogenase Complex
  • Succinate Dehydrogenase
  • Selenium
  • Sodium Selenite
Topics
  • Alkylating Agents (toxicity)
  • Animals
  • Anticarcinogenic Agents (administration & dosage, therapeutic use)
  • Citric Acid Cycle
  • Dietary Supplements
  • Diethylnitrosamine (toxicity)
  • Humans
  • Isocitrate Dehydrogenase (metabolism)
  • Ketoglutarate Dehydrogenase Complex (metabolism)
  • Kidney (drug effects, enzymology)
  • Liver Neoplasms, Experimental (chemically induced, drug therapy, enzymology, prevention & control)
  • Malate Dehydrogenase (metabolism)
  • Male
  • Mitochondria (enzymology)
  • Mitochondria, Liver (drug effects, enzymology)
  • Rats
  • Rats, Wistar
  • Selenium (administration & dosage, metabolism)
  • Sodium Selenite (administration & dosage, therapeutic use)
  • Succinate Dehydrogenase (metabolism)

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