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Efficacy of usual antidepressant dosing regimens of fluoxetine in panic disorder: randomised, placebo-controlled trial.

AbstractBACKGROUND:
Although serotonin reuptake inhibitors are effective in panic disorder, questions concerning whether doses associated with antidepressant efficacy are also effective for panic disorder remain.
AIMS:
To assess the efficacy of the usual antidepressant dose of fluoxetine in treating full panic attacks.
METHOD:
Patients with panic disorder were randomised to placebo or to fluoxetine initiated at 10 mg daily for 1 week and then increased to 20 mg daily. The trial lasted 12 weeks, but after 6 weeks patients who had failed to achieve a satisfactory response were eligible for dose escalation to a maximum of 60 mg of fluoxetine daily.
RESULTS:
Fluoxetine was associated with a statistically significantly greater proportion of panic-free patients compared with placebo after 6 weeks and at end-point.
CONCLUSIONS:
Fluoxetine at a dose of 20 mg daily is safe and efficacious in reducing symptoms of panic disorder. Patients who fail to obtain a satisfactory response at 20 mg daily may benefit from further dose increases.
AuthorsD Michelson, C Allgulander, K Dantendorfer, A Knezevic, D Maierhofer, V Micev, V R Paunovic, I Timotijevic, N Sarkar, L Skoglund, S C Pemberton
JournalThe British journal of psychiatry : the journal of mental science (Br J Psychiatry) Vol. 179 Pg. 514-8 (Dec 2001) ISSN: 0007-1250 [Print] England
PMID11731354 (Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
Chemical References
  • Antidepressive Agents, Second-Generation
  • Serotonin Uptake Inhibitors
  • Fluoxetine
Topics
  • Adult
  • Antidepressive Agents, Second-Generation (administration & dosage, adverse effects)
  • Double-Blind Method
  • Drug Administration Schedule
  • Female
  • Fluoxetine (administration & dosage, adverse effects)
  • Humans
  • Male
  • Middle Aged
  • Panic Disorder (drug therapy)
  • Psychiatric Status Rating Scales
  • Serotonin Uptake Inhibitors (administration & dosage, adverse effects)
  • Single-Blind Method
  • Treatment Outcome

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