Abstract | BACKGROUND AND OBJECTIVES: METHODS: Thirty healthy parturients requesting analgesia were enrolled in this randomized and open-label study. Each patient was in spontaneous labor at greater than 5 cm cervical dilatation. Using a combined spinal and epidural technique, patients received either intrathecal sufentanil 10 microg (SUF = intrathecal sufentanil group) or epidural plain bupivacaine 0.25%, 12 mL (BUPIV = epidural bupivacaine group). Analgesia was assessed using a visual analog scale, and blood samples for oxytocin and cortisol plasma concentration measurements were collected immediately before analgesia and 15, 30, 60, and 90 minutes after induction of the analgesia. Plasma cortisol and oxytocin concentrations were determined by specific radioimmunoassay. The values were expressed as mean +/- SEM. RESULTS: Intrathecal sufentanil provided faster and more complete analgesia within 15 and 30 minutes of its administration, compared with epidural bupivacaine. Plasma oxytocin concentrations were similar in the 2 groups before analgesia (7.24 +/- 2.1 and 6.6 +/- 3.1 pg/mL SUF and BUPIV, respectively). It decreased significantly in the SUF and increased in the BUPIV after analgesic administration. Cortisol concentrations were elevated in both groups before analgesia (51.6 +/- 5.3 and 54.2 +/- 4.8 microg/dL SUF and BUPIV, respectively). Both analgesic treatments significantly decreased the plasma cortisol levels. CONCLUSIONS:
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Authors | R M Stocche, J G Klamt, J Antunes-Rodrigues, L V Garcia, A C Moreira |
Journal | Regional anesthesia and pain medicine
(Reg Anesth Pain Med)
2001 Nov-Dec
Vol. 26
Issue 6
Pg. 545-50
ISSN: 1098-7339 [Print] England |
PMID | 11707794
(Publication Type: Clinical Trial, Comparative Study, Journal Article, Randomized Controlled Trial)
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Chemical References |
- Analgesics, Opioid
- Oxytocin
- Sufentanil
- Hydrocortisone
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Topics |
- Adult
- Analgesia, Epidural
- Analgesia, Obstetrical
- Analgesics, Opioid
- Blood Pressure
(drug effects)
- Female
- Heart Rate
(drug effects)
- Humans
- Hydrocortisone
(blood)
- Injections, Spinal
- Labor Stage, First
(blood)
- Oxytocin
(blood)
- Pregnancy
- Radioimmunoassay
- Respiratory Mechanics
(drug effects)
- Sufentanil
(administration & dosage)
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