Abstract | BACKGROUND: METHODS AND RESULTS: Twenty-six women (aged 52+/-8.2 years) with SLE and a history of CVD (SLE cases) were compared with 26 age-matched women with SLE but without manifest CVD (SLE controls) and 26 age-matched population-based control women (population controls). Common carotid intima-media thickness (IMT) was measured by B-mode ultrasound as a surrogate measure of atherosclerosis. SLE cases had increased IMT compared with SLE controls (P=0.03) and population controls (P=0.001), whereas IMT of SLE controls did not differ from population controls. SLE cases had raised plasma concentrations of circulating oxidized LDL ( OxLDL; P=0.03), as measured by the monoclonal antibody EO6, and autoantibodies to epitopes of OxLDL (P<0.001); dyslipidemia with raised triglycerides (P<0.001) and lipoprotein(a) (P=0.002) and decreased HDL-cholesterol concentrations (P=0.03); raised alpha-1-antitrypsin (P=0.002), lupus anticoagulant (P=0.007), and homocysteine levels (P=0.03); more frequent osteoporosis (P=0.03); and a higher cumulative prednisolone dose (P=0.05) compared with SLE controls. Disease duration, smoking, blood pressure, body mass index, and diabetes mellitus did not differ significantly between the groups. CONCLUSIONS: alpha set of distinct CVD risk factors separate SLE cases from SLE controls and population controls. If confirmed in a prospective study, they could be used to identify SLE patients at high risk for CVD in order to optimize treatment.
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Authors | E Svenungsson, K Jensen-Urstad, M Heimbürger, A Silveira, A Hamsten, U de Faire, J L Witztum, J Frostegård |
Journal | Circulation
(Circulation)
Vol. 104
Issue 16
Pg. 1887-93
(Oct 16 2001)
ISSN: 1524-4539 [Electronic] United States |
PMID | 11602489
(Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)
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Chemical References |
- Autoantibodies
- Biomarkers
- Epitopes
- Lipids
- Lipoproteins
- Lipoproteins, LDL
- oxidized low density lipoprotein
- Malondialdehyde
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Topics |
- Autoantibodies
(blood)
- Biomarkers
(blood)
- Cardiovascular Diseases
(blood, diagnosis, epidemiology)
- Carotid Artery, Common
(diagnostic imaging)
- Case-Control Studies
- Cohort Studies
- Comorbidity
- Epitopes
(blood, immunology)
- Female
- Humans
- Lipids
(blood)
- Lipoproteins
(blood)
- Lipoproteins, LDL
(blood, immunology)
- Lupus Erythematosus, Systemic
(blood, diagnosis, epidemiology)
- Malondialdehyde
(immunology)
- Middle Aged
- Osteoporosis
(diagnosis, epidemiology)
- Prevalence
- Risk Factors
- Sweden
(epidemiology)
- Ultrasonography
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