Abstract | OBJECTIVE: To study the protective effect of 1,8-dihydroxy-3,5- dimethoxyxanthone (Xan-I) 1-hydroxy-5-dimethoxyxanthone(Xam-II) and 1-hydroxy-3,7,8-trimethoxyanthone (Xan-III) on arrhythmia induced by myocardial ischemia- reperfusion injury and their mechanism. METHOD: A rat model was used. The experimental result shows that. RESULT: CONCLUSION: It follows that the protective effect of Xans on myocardial ischemia reperfusion induced by arrhythmia might be associated with the reduction of myocardial lipid peroxidation and the enhancement of SOD activity, and the amount and site of- OH(hydroxy) and -OCH3 (methoxy) on the benzenoid structure may be related to the affinity of Xan.
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Authors | Q He, S Xu, B Peng |
Journal | Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica
(Zhongguo Zhong Yao Za Zhi)
Vol. 23
Issue 9
Pg. 556-7, back cover
(Sep 1998)
ISSN: 1001-5302 [Print] China |
PMID | 11599392
(Publication Type: Journal Article)
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Chemical References |
- Drugs, Chinese Herbal
- Xanthenes
- Xanthones
- xanthone
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Topics |
- Animals
- Arrhythmias, Cardiac
(etiology, prevention & control)
- Drugs, Chinese Herbal
(chemistry, pharmacology)
- Magnoliopsida
(chemistry)
- Myocardial Reperfusion Injury
(complications)
- Myocardium
(metabolism)
- Phytotherapy
- Plants, Medicinal
(chemistry)
- Random Allocation
- Rats
- Rats, Sprague-Dawley
- Xanthenes
(isolation & purification, pharmacology)
- Xanthones
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