[Sequencing-based typing of HLA-DPB1 and DQB1 exon 2 in patients with type 1 diabetes mellitus].

Abstract

OBJECTIVE:

To investigate the correlation between type 1 diabetes mellitus susceptibility and HLA-DPB1 and DQB1 genes in Shandong Han population.

METHODS:

HLA-DPB1 and DQB1 genes analysis were performed by sequencing-based typing in 52 type 1 diabetes mellitus patients and 38 normal controls.

RESULTS:

The frequency of DPB1*2201 in diabetics was significantly higher than that in controls(26.92% vs 5.26%, P<0.01), but the frequency of DPB1*0402 in diabetics was significantly lower than that in controls(11.54% vs 34.21%, P<0.01). The frequencies of DQB1*0201, *0303 and *0604 in diabetics were higher than those in controls (24.04% vs 10.53%, P< 0.01; 22.12% vs 6.58%, P<0.05; 19.23% vs 7.89%, P<0.05), while the frequency of DQB1*0301 in diabetics was significantly lower than that in controls (4.81% vs 25.00%, P<0.01).

CONCLUSION:

DPB1*2201, DQB1*0201, *0303 and *0604 may be susceptible alleles, and DPB1*0402 and DQB1*0301 may be protective alleles in patients with type 1 diabetes mellitus.

• Authors: S Zhang, W Xing, B Ke, H Yan, Z Jiang
• Journal: Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics (Zhonghua Yi Xue Yi Chuan Xue Za Zhi) Vol. 18 Issue 5 Pg. 362-5 (Oct 2001) ISSN: 1003-9406 [Print] China
• PMID: 11592043 (Publication Type: English Abstract, Journal Article)

Chemical References

• HLA-DP Antigens
• HLA-DP beta-Chains
• HLA-DPB1 antigen
• HLA-DQ Antigens
• HLA-DQ beta-Chains
• HLA-DQB1 antigen

Topics

• Adolescent
• Adult
• Base Sequence
• Diabetes Mellitus, Type 1 (genetics)
• Exons
• Female
• Gene Frequency
• HLA-DP Antigens (genetics)
• HLA-DP beta-Chains
• HLA-DQ Antigens (genetics)
• HLA-DQ beta-Chains
• Humans
• Male
• Molecular Sequence Data