Abstract | BACKGROUND: OBJECTIVE: METHODS: Mice were sensitized with freshly ground whole peanut in the presence of cholera toxin and boosted 1 and 3 weeks later. FAHF-1 treatment was initiated 1 week later and continued for 7 weeks. After treatment, mice were challenged with peanut, and anaphylactic symptoms, body temperatures, and plasma histamine and IgE levels were measured. T-cell proliferative responses and cytokine production were also determined. RESULTS: FAHF-1 completely blocked peanut-induced anaphylactic symptoms and markedly reduced mast cell degranulation and histamine release. Peanut-specific serum IgE levels were significantly reduced by 2 weeks of treatment at the time of challenge, and they remained lower 4 weeks after discontinuation of treatment. FAHF-1 significantly reduced peanut-induced lymphocyte proliferation as well as IL-4, IL-5, and IL-13 synthesis but not IFN-gamma synthesis. No toxic effects on liver or kidney functions were observed, nor was there any overall immune suppression. CONCLUSION:
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Authors | X M Li, T F Zhang, C K Huang, K Srivastava, A A Teper, L Zhang, B H Schofield, H A Sampson |
Journal | The Journal of allergy and clinical immunology
(J Allergy Clin Immunol)
Vol. 108
Issue 4
Pg. 639-46
(Oct 2001)
ISSN: 0091-6749 [Print] United States |
PMID | 11590394
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)
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Chemical References |
- Anti-Allergic Agents
- Cytokines
- Food Allergy Herbal Formula-1
- Immunoglobulin A
- Immunoglobulin G
- Plant Extracts
- Immunoglobulin E
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Topics |
- Administration, Oral
- Anaphylaxis
(prevention & control)
- Animals
- Anti-Allergic Agents
(therapeutic use)
- Antibody Specificity
- Arachis
(adverse effects)
- Cell Degranulation
- Cytokines
(biosynthesis)
- Female
- Food Hypersensitivity
(prevention & control)
- Immunoglobulin A
(blood)
- Immunoglobulin E
(immunology)
- Immunoglobulin G
(blood)
- Kidney Function Tests
- Liver Function Tests
- Lymphocyte Activation
(drug effects)
- Mast Cells
(immunology)
- Mice
- Mice, Inbred C3H
- Plant Extracts
(therapeutic use)
- Th2 Cells
(drug effects)
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