Outcome of growth hormone therapy in children with growth hormone deficiency showing an inadequate response to growth hormone-releasing hormone.
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| Abstract |
Saizen (recombinant growth hormone [GH]), 0.2 mg/(kg x wk), was given in an open-label fashion for an average of 51 mo to 27 children with presumed idiopathic GH deficiency who had withdrawn from a trial of Geref (recombinant GH-releasing hormone [GHRH] 1-29) because of inadequate height velocity (HV) (25 children), the onset of puberty (1 child), or injection site reactions (1 child). Measurements were made every 3-12 mo of a number of auxologic variables, including HV, height standard deviation score, and bone age. The children in the study showed excellent responses to Saizen. Moreover, first-year growth during Saizen therapy was inversely correlated with the GH response to provocative GHRH testing carried out 6 and 12 mo after the initiation of Geref treatment. These findings indicate that GH is effective in accelerating growth in GH-deficient children who do not show or maintain a satisfactory response to treatment with GHRH. In addition, they suggest that the initial response to GH therapy used in this way can be predicted by means of provoc-ative testing.
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| Authors | P Saenger, O H Pescovitz, B B Bercu, F T Murray, H Landy, J Brentzel, L O'Dea, B Hanson, C Howard, E O Reiter, Geref International Study Group |
| Journal | Endocrine (Endocrine) Vol. 15 Issue 1 Pg. 51-6 (Jun 2001) ISSN: 1355-008X [Print] United States |
| PMID | 11572326 (Publication Type: Clinical Trial, Journal Article, Multicenter Study) |
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