Safety and efficacy of beta-blockers in the treatment of stable angina pectoris.

Abstract

In stable exercise-induced angina pectoris, beta-blockers exert their beneficial effects mainly through a reduction in heart rate, blood pressure. and contractility. Additional beneficial effects are an improvement in myocardial oxygen supply through a redistribution of coronary flow, a lengthening of diastole, a facilitation of aerobic metabolism, and a rightward shift of the oxygen-hemoglobin dissociation curve. Cardioselective beta-blockers can be expected to have fewer side effects than the nonselective drugs. Apart from a reduction in anginal attack rate and an improvement in exercise capacity, a reduction in silent ischemia may be desirable when treating patients with stable effort angina, beta-blockers effectively reduce asymptomatic ischemia. Bisoprolol is a new beta1-selective beta-blocker with a clear 24-h duration of action regarding symptoms and improvement of exercise capacity in patients with stable exercise-induced angina pectoris. Bisoprolol 10 mg and atenolol 100 mg are equipotent in achieving these effects.

• Authors: E D de Muinck, K I Lie
• Journal: Journal of cardiovascular pharmacology (J Cardiovasc Pharmacol) Vol. 16 Suppl 5 Pg. S123-8 ( 1990) ISSN: 0160-2446 [Print] United States
• PMID: 11527115 (Publication Type: Journal Article, Review)

Chemical References

• Adrenergic beta-Antagonists
• Bisoprolol

Topics

• Adrenergic beta-Antagonists (adverse effects, pharmacology, therapeutic use)
• Angina Pectoris (drug therapy)
• Animals
• Bisoprolol (pharmacology, therapeutic use)
• Blood Pressure (drug effects, physiology)
• Heart Rate (drug effects, physiology)
• Humans
• Myocardial Contraction (drug effects, physiology)
• Myocardial Ischemia (drug therapy)
• Treatment Outcome