Constituents of the root bark of Severinia buxifolia collected in Hainan.

Abstract

Two new tetranortriterpenoids, 7-isovaleroylcycloseverinolide (1) and 7-isovaleroylcycloepiatalantin (2), together with 28 known compounds, were isolated and characterized from the root bark of Severinia buxifolia collected in Hainan. The structures of 1 and 2 were elucidated on the basis of spectral evidence including 2D NMR and X-ray techniques. The cytotoxicity of several acridone alkaloid isolates (3-8) was evaluated against a small tumor cell panel.

• Authors: T S Wu, C M Chen, F W Lin
• Journal: Journal of natural products (J Nat Prod) Vol. 64 Issue 8 Pg. 1040-3 (Aug 2001) ISSN: 0163-3864 [Print] United States
• PMID: 11520222 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• 7-isovaleroylcycloepiatalantin
• 7-isovaleroylcycloseverinolide
• Acridines
• Acridones
• Antineoplastic Agents, Phytogenic
• Drugs, Chinese Herbal
• Triterpenes
• acridone

Topics

• Acridines (chemistry, pharmacology)
• Acridones
• Antineoplastic Agents, Phytogenic (chemistry, isolation & purification, pharmacology)
• Carcinoma, Hepatocellular
• Colonic Neoplasms
• Crystallography, X-Ray
• Drugs, Chinese Herbal (chemistry, isolation & purification, pharmacology)
• Humans
• KB Cells
• Magnetic Resonance Spectroscopy
• Molecular Structure
• Plant Roots (chemistry)
• Plants, Medicinal (chemistry)
• Taiwan
• Triterpenes (chemistry, isolation & purification, pharmacology)
• Tumor Cells, Cultured (drug effects, metabolism)