Anticonvulsant activity of N,N'-bis[3-(3-substituted urea)propyl]piperazines.

Abstract

Several N,N'-bis[3-(3-substituted urea)propyl]piperazines were synthesized and characterized by their sharp melting points, elemental analyses, and IR spectra. All substituted piperazines were found to possess anticonvulsant activity, which was reflected by 20-70% protection observed against pentylenetetrazol-induced seizures in mice. Some of these compounds inhibited oxidation of pyruvic acid by rat brain homogenate. No correlation could be observed between the anticonvulsant activity possessed by these substituted piperazines and their ability to inhibit the oxidation of pyruvic acid.

• Authors: A K Chaturvedi, J P Barthwal, S S Parmar, V I Stenberg
• Journal: Journal of pharmaceutical sciences (J Pharm Sci) Vol. 64 Issue 3 Pg. 454-6 (Mar 1975) ISSN: 0022-3549 [Print] United States
• PMID: 1151634 (Publication Type: Journal Article, Research Support, U.S. Gov't, Non-P.H.S., Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Anticonvulsants
• Piperazines
• Pyruvates
• Urea
• Pentylenetetrazole

Topics

• Animals
• Anticonvulsants (pharmacology, toxicity)
• Brain (metabolism)
• In Vitro Techniques
• Lethal Dose 50
• Male
• Oxygen Consumption (drug effects)
• Pentylenetetrazole
• Piperazines (pharmacology, toxicity)
• Pyruvates (metabolism)
• Rats
• Seizures (chemically induced)
• Urea (analogs & derivatives, pharmacology)