Abstract | OBJECTIVE: The main objective of this study was to evaluate well-being and physical activity of 248 hypertensive patients, including 177 females, who had previously been included in the Latin-American Study on Lacidipine in Hypertension (LASTLHY). SUBJECTS, MATERIALS AND METHODS: This open study was carried out in 12 clinical centers in Argentina, Brazil, Colombia, Mexico and Venezuela, to compare, over a period of 16 weeks, the antihypertensive action of a fixed-dose, once daily of 4 mg lacidipine administered orally to 120 patients and 30 mg nifedipine GITS (Gastro-Intestinal Therapeutic System) administered to 128 patients, aged between 40 and 65 years. All patients had mild to moderate hypertension and treatment was begun at the end of a one-week placebo run-in period (end of week -1). Well-being and physical activity were assessed by means of single questionnaire, which reflected the physical and cultural diversities amongst the clinical centers and patients. The questionnaire included 13 multiple-choice and 8 contingent open questions. The score of each question was multiplied by a coefficient related to the importance of each question to the patient (semipersonalization); the coefficient was obtained from cultural and socioeconomic data collected at the time of enrollment. The semipersonalization was carried out by a blind psychological study with respect to the medication and had a high repeatability in the assignment of personalized coefficients to the score of each question. The scores of each question were added to obtain an overall well-being and activity scoring. The possible theoretical range for the overall scoring in this study was 10 - 124. RESULTS: See Table 1. CONCLUSION:
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Authors | M Velasco, E Lezama, R Hernández-Hernández, M J Armas-Hernández, M C Armas-Padilla, L Alcocer |
Journal | International journal of clinical pharmacology and therapeutics
(Int J Clin Pharmacol Ther)
Vol. 39
Issue 8
Pg. 325-30
(Aug 2001)
ISSN: 0946-1965 [Print] Germany |
PMID | 11515706
(Publication Type: Comparative Study, Journal Article, Multicenter Study, Research Support, Non-U.S. Gov't)
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Chemical References |
- Antihypertensive Agents
- Calcium Channel Blockers
- Dihydropyridines
- lacidipine
- Nifedipine
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Topics |
- Activities of Daily Living
- Administration, Oral
- Adult
- Aged
- Antihypertensive Agents
(therapeutic use)
- Calcium Channel Blockers
(therapeutic use)
- Dihydropyridines
(therapeutic use)
- Exercise
- Female
- Health Surveys
- Humans
- Hypertension
(drug therapy, psychology)
- Male
- Middle Aged
- Nifedipine
(therapeutic use)
- Psychometrics
- Quality of Life
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