[Experience in the use of vessel due F (sulodexide) in patients with suppurative-necrotic forms of diabetic foot without critical ischemia].

Abstract

AIM:

To evaluate effectiveness of sulodexide in patients with pyonecrotic complications of diabetic foot.

MATERIAL AND METHOD:

Sulodexide was given to 15 patients which were examined for blood fibrinogen, foot tissues saturation with oxygen, microbic contamination of the wound tissue. In addition, ultrasound dopplerography of foot arteries, laser doppler flowmetry were performed.

RESULTS:

Fibrinogen in peripheral blood fell, arteriovenous shunting diminished, capillary blood flow and oxygen saturation of the tissues improved.

CONCLUSION:

Even early sulodexide treatment is effective at different stages of the pathological process in diabetic patients with severe pyonecrotic lesion of the lower limbs as it recovers microcirculatory blood flow.

• Authors: A M Svetukhin, A B Zemlianoĭ, S A Orudzheva, M I Titova, V G Rudneva, L V Elagina, M V Pavlova, R P Terekhova, E I Bozh'eva, L S Makhmudova
• Journal: Terapevticheskii arkhiv (Ter Arkh) Vol. 73 Issue 4 Pg. 31-3 ( 2001) ISSN: 0040-3660 [Print] Russia (Federation)
• Vernacular Title: Opyt primeneniia Vessel dué F (sulodeksid) u bol'nykh s gnoĭno-nekroticheskimi formami diabeticheskoĭ stopy bez kriticheskoĭ ishemii.
• PMID: 11494443 (Publication Type: Comparative Study, English Abstract, Journal Article)

Chemical References

• Glycosaminoglycans
• Hypoglycemic Agents
• glucuronyl glucosamine glycan sulfate

Topics

• Diabetic Foot (drug therapy, pathology, physiopathology)
• Glycosaminoglycans (administration & dosage, therapeutic use)
• Humans
• Hypoglycemic Agents (administration & dosage, therapeutic use)
• Microcirculation
• Necrosis
• Suppuration
• Time Factors