Fibrin monomer could be a useful predictor of pulmonary embolism after total hip arthroplasty: preliminary report.

Abstract

We examined 17 total hip arthroplasty patients in order to develop a method for the predictive diagnosis of pulmonary embolism (PE) after joint arthroplasty. Scintigraphy revealed the presence of PE in 4 patients. Prothrombin time (PT), activated partial thromboplastin time (aPTT), antithrombin III (ATIII), and thrombin-AT III complex (TAT) did not show significant differences between patients with and without PE. D-dimer 7 days after surgery showed significant differences between patients with and without PE. Fibrin monomer (FM) increased sharply after surgery, and it was significantly different between the patients with and without PE immediately after surgery and 2 days after surgery. Our findings suggest the importance of FM in the predictive diagnosis of pulmonary embolism after total hip arthroplasty, and 40 microg/ml or higher levels with our measurement method could represent a high-risk condition.

• Authors: T Kubo, I Kitajima, A Makinodan, S Niratsuka, S Inoue, G Otsuka, S Ohashi, K Ueshima, Y Hirasawa
• Journal: Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association (J Orthop Sci) Vol. 6 Issue 2 Pg. 119-22 ( 2001) ISSN: 0949-2658 [Print] Japan
• PMID: 11484095 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Fibrin Fibrinogen Degradation Products
• fibrinmonomer

Topics

• Aged
• Arthroplasty, Replacement, Hip
• Female
• Fibrin Fibrinogen Degradation Products (analysis)
• Humans
• Male
• Middle Aged
• Postoperative Complications (diagnosis)
• Predictive Value of Tests
• Prognosis
• Pulmonary Embolism (diagnosis, diagnostic imaging, etiology)
• Radionuclide Imaging