A randomized controlled trial comparing amoxicillin and azithromycin for the treatment of Chlamydia trachomatis in pregnancy.

Abstract

OBJECTIVE:

Our goal was to compare the efficacy of azithromycin with that of amoxicillin for the treatment of Chlamydia trachomatis infection during pregnancy.

STUDY DESIGN:

A randomized controlled trial of pregnant women with cervical C trachomatis infection receiving care at two inner-city, university-based prenatal clinics. Pregnant women were randomly assigned to receive either oral amoxicillin, 500 mg, three times daily for 7 days, or oral azithromycin, 1 g, in a single dose. Partners were referred for treatment. Tests of cure were scheduled 4 weeks after initiation of treatment. Statistical analysis was performed by using the Student t test and chi2 analysis.

RESULTS:

One hundred twenty-nine pregnant women were enrolled, and 110 (85%) completed the protocol. There was similar treatment efficacy between amoxicillin and azithromycin (58% vs 64%, respectively,P =.56). In the amoxicillin group 3 women (5.5%) were intolerant, compared with 6 (10.9%) in the azithromycin group (P =.31).

CONCLUSION:

Amoxicillin and azithromycin are equally efficacious in the treatment of cervical C trachomatis during pregnancy.

• Authors: G F Jacobson, A M Autry, R S Kirby, E M Liverman, R U Motley
• Journal: American journal of obstetrics and gynecology (Am J Obstet Gynecol) Vol. 184 Issue 7 Pg. 1352-4; discussion 1354-6 (Jun 2001) ISSN: 0002-9378 [Print] United States
• PMID: 11408852 (Publication Type: Clinical Trial, Comparative Study, Journal Article, Randomized Controlled Trial)

Chemical References

• Anti-Bacterial Agents
• Penicillins
• Amoxicillin
• Azithromycin

Topics

• Adult
• Amoxicillin (adverse effects, therapeutic use)
• Anti-Bacterial Agents (adverse effects, therapeutic use)
• Azithromycin (adverse effects, therapeutic use)
• Chlamydia Infections (drug therapy)
• Female
• Humans
• Penicillins (adverse effects, therapeutic use)
• Pregnancy
• Pregnancy Complications, Infectious (drug therapy)
• Treatment Outcome