[Activity of cathepsin B and cystatins in the placenta during EPH-gestosis].

Abstract

Activity of cathepsin B using Bz-DL-Arg-pNA contents of SH-group by means of Ellman method, activity of cystatins against papain using casein as a substrate and contents of deoxyribonuclein acids by Burton method were determined in 64 placentas of pregnancies with EPH-gestosis and in 36 placentas of physiological pregnancies. The placentas from pregnancies with EPH-gestosis showed markedly higher activity of cathepsin B, no difference in the contents of SH-group, slightly higher activity of cystatins and they contain less deoxyribonucleic acids than the placentas from physiological pregnancies. The obtained results show that proteolytic--anti-proteolytic balance in placentas from pregnacies with EPH-gestosis is changed to the advantage of cathepsin B. This protease may in formation of structural and functional changes observed in placentas during EPH-gestosis.

• Authors: M al-Hameri, W Roszkowska-Jakimiec, M Gacko, M Chlabicz
• Journal: Ginekologia polska (Ginekol Pol) Vol. 72 Issue 2 Pg. 61-6 (Feb 2001) ISSN: 0017-0011 [Print] Poland
• Vernacular Title: Aktywność katepsyny B i aktywność cystatyn w łozysku EPH-gestozowym.
• PMID: 11387992 (Publication Type: English Abstract, Journal Article)

Chemical References

• Cystatins
• Cathepsin B

Topics

• Cathepsin B (metabolism)
• Cystatins (metabolism)
• Female
• Humans
• Placenta (metabolism)
• Pre-Eclampsia (metabolism)
• Pregnancy