Calcitonin gene-related peptide-mediated ischemic preconditioning in the rat heart: influence of age.

Abstract

In the present study, we examined whether age-related reduction of ischemic preconditioning is related to calcitonin gene-related peptide (CGRP) release in the rat heart. Thirty minutes of global ischemia and 40 min of reperfusion caused a significant decrease of cardiac function and a marked increase of creatine kinase (CK) release at 2, 6 and 20 months of age. Ischemic preconditioning and pretreatment with CGRP for 5 min significantly improved cardiac function and reduced CK release during reperfusion at 2 and 6 months of age but not at 20 months of age. The content of CGRP in the coronary effluent during ischemic preconditioning was significantly increased in the first cycle at 2, 6 months of age but not at 20 months of age. These results suggest that the protection afforded by ischemic preconditioning is decreased in aging hearts, and the age-related change may be related to reduction of the release and effect of CGRP in the rat heart.

• Authors: R Lu, C P Hu, H W Deng, Y J Li
• Journal: Regulatory peptides (Regul Pept) Vol. 99 Issue 2-3 Pg. 183-9 (Jun 15 2001) ISSN: 0167-0115 [Print] Netherlands
• PMID: 11384781 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Calcitonin Gene-Related Peptide

Topics

• Aging (metabolism, physiology)
• Animals
• Calcitonin Gene-Related Peptide (metabolism, physiology)
• In Vitro Techniques
• Ischemic Preconditioning, Myocardial (methods)
• Male
• Myocardium (metabolism)
• Rats
• Rats, Sprague-Dawley