Elevated tacrolimus trough levels in association with mycophenolate mofetil-induced diarrhea: a case report.

Abstract	The combination of tacrolimus (TAC) and mycophenolate mofetil (MMF) is frequently used for immunosuppression after organ transplantation (Tx), but the pharmacokinetics and interactions between the two drugs are poorly elucidated. We describe here the increase of TAC trough levels during MMF-induced diarrhea in a 8-yr-old boy after kidney Tx. Early dose reduction of TAC, together with short-term monitoring of TAC trough levels in the presence of diarrhea, is recommended.
Authors	M Frühwirth, H Fischer, B Simma, H Ellemunter
Journal	Pediatric transplantation (Pediatr Transplant) Vol. 5 Issue 2 Pg. 132-4 (Apr 2001) ISSN: 1397-3142 [Print] Denmark
PMID	11328552 (Publication Type: Case Reports, Journal Article)
Chemical References	Immunosuppressive Agents Mycophenolic Acid Tacrolimus
Topics	Child Drug Interactions Drug Monitoring Humans Immunosuppressive Agents (administration & dosage, adverse effects, blood) Male Mycophenolic Acid (adverse effects, analogs & derivatives) Tacrolimus (administration & dosage, blood)

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