Preliminary report: effect of adrenal androgen and estrogen on bone maturation and bone mineral density.

Abstract

To clarify the independent physiological roles of adrenal androgen and estrogen on bone growth, we compared the lumbar spine bone mineral density (BMD) in prepubertal girls with virilizing congenital adrenal hyperplasia (CAH) (n = 17) and girls with central precocious puberty (CPP) (n = 18). When BMD was analyzed according to chronologic age, no significant differences were found between CPP and CAH patients. However, when adjusted to bone age, BMD was statistically higher in CAH than in CPP subjects. This finding suggests that adrenal androgen, as well as estrogen, plays an important role in increasing BMD. Adrenal androgen may act on bone not only as androgen, but as estrogen after having been metabolized into an aromatized bone-active compound in peripheral tissues, such as bone and fat. Therefore, adrenal androgen may have a more important role in increasing BMD than previously realized.

• Authors: O Arisaka, M Hoshi, S Kanazawa, M Numata, D Nakajima, S Kanno, M Negishi, K Nishikura, A Nitta, M Imataka, T Kuribayashi, K Kano
• Journal: Metabolism: clinical and experimental (Metabolism) Vol. 50 Issue 4 Pg. 377-9 (Apr 2001) ISSN: 0026-0495 [Print] United States
• PMID: 11288028 (Publication Type: Clinical Trial, Journal Article)
• Copyright: Copyright 2001 by W.B. Saunders Company

Chemical References

• Androgens
• Estrogens

Topics

• Absorptiometry, Photon
• Adrenal Glands (physiology)
• Adrenal Hyperplasia, Congenital (metabolism, physiopathology)
• Age Determination by Skeleton
• Androgens (physiology)
• Bone Density (physiology)
• Bone Development (physiology)
• Child
• Estrogens (physiology)
• Female
• Humans
• Puberty, Precocious (metabolism, physiopathology)