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Systematic review of combination antiretroviral therapy with didanosine plus hydroxyurea: a partial solution to Africa's HIV/AIDS problem?

Abstract
Effective antiretroviral therapy remains beyond the reach of most human immunodeficiency virus (HIV)-infected persons living in the third world because of its tremendous cost. The cancer drug, hydroxyurea, inhibits HIV-1 replication in vitro and, when combined with didanosine (ddI), results in significant antiretroviral synergy. In vivo, hydroxyurea specifically targets quiescent lymphocytes and macrophages, important cellular reservoirs for HIV-1, and the combination of ddI plus hydroxyurea effectively reduces plasma HIV-1 RNA levels. Combination ddI-hydroxyurea costs about one-eighth as much as currently recommended triple drug combinations, and several countries in Africa are exploring the feasibility of widescale use of ddI-hydroxyurea for their HIV-infected populations. Intrigued by its potential relevance for Africa, the authors reviewed the literature on the in vitro and clinical efficacy of ddI plus hydroxyurea against HIV. The combination of ddI plus hydroxyurea is an effective and potentially more affordable regimen for HIV-infected persons living in poorer countries.
AuthorsI Sanne, R A Smego Jr, B V Mendelow
JournalInternational journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases (Int J Infect Dis) Vol. 5 Issue 1 Pg. 43-8 ( 2001) ISSN: 1201-9712 [Print] Canada
PMID11285159 (Publication Type: Journal Article, Review, Systematic Review)
Chemical References
  • Anti-HIV Agents
  • Zidovudine
  • Didanosine
  • Hydroxyurea
Topics
  • Africa
  • Anti-HIV Agents (pharmacokinetics, pharmacology, therapeutic use)
  • CD4 Lymphocyte Count
  • Didanosine (pharmacokinetics, pharmacology, therapeutic use)
  • Drug Therapy, Combination
  • HIV Infections (drug therapy, immunology, pathology)
  • Humans
  • Hydroxyurea (pharmacokinetics, pharmacology, therapeutic use)
  • MEDLINE
  • Treatment Outcome
  • Viral Load
  • Zidovudine (pharmacokinetics, pharmacology)

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