Inhibition of cutaneous UV light-induced tumor necrosis factor-alpha protein production by Allotrap 1258, a novel immunomodulatory peptide.

Abstract

Peptides derived from the heavy chain of the HLA Class-I molecules have been shown to modulate immune responses both in vivo and in vitro. Using a computer-aided rational drug design approach, novel immunomodulatory peptides were designed based on peptide 2702.75-85, derived from HLA-B2702. Several peptides were identified which had increased immunomodulatory activity, including peptides RDP1258 and its D-isomer the peptide Allotrap 1258. The present study using Skh/hr hairless mouse skin model evaluated the in vivo effects of Allotrap 1258 on acute UVB-induced skin inflammation. Here we demonstrate that intraperitoneal administration of Allotrap 1258 1 h prior to UV exposure resulted in significantly diminished levels of UV-induced tumor necrosis factor (TNF)-alpha protein production in the epidermis but had no effect on other parameters of the acute UV-induced inflammatory response. By virtue of its ability to suppress TNF-alpha protein production, Allotrap 1258 could prove to be an effective modulator of inflammatory responses.

• Authors: T M Oberyszyn, F M Robertson, K L Tober, M S Ross, M L Parrett, T A Wilgus, S Iyer, J Woo, R Buelow
• Journal: Photochemistry and photobiology (Photochem Photobiol) Vol. 73 Issue 2 Pg. 184-90 (Feb 2001) ISSN: 0031-8655 [Print] United States
• PMID: 11272733 (Publication Type: Journal Article)

Chemical References

• Adjuvants, Immunologic
• Peptides
• Tumor Necrosis Factor-alpha
• allotrap

Topics

• Adjuvants, Immunologic (pharmacology)
• Animals
• Female
• Immunohistochemistry
• Mice
• Mice, Hairless
• Peptides (pharmacology)
• Skin (immunology, pathology, radiation effects)
• Tumor Necrosis Factor-alpha (biosynthesis, genetics)
• Ultraviolet Rays (adverse effects)