[The effect of polysaccharide from typhoid bacteria on hemopoietic stem cells].

Abstract

A study was made of dynamics of the content of colony-forming units (CFU) in the spleen and the bone marrow of the nonirradiated F1 (CBA times C57BL) mice to which polysaccharide (PS) from typhoid bacilli was administered. A method of exogenous colony formation was used in this work. A single PS administration increased the CFU count in the bone marrow (2-2 1/2 times) and in the spleen (3 times). Repeated (6- and 9- time) administration of PS was not more effective than a single one. Apparently PS acted as an inductor which caused proliferation of the stem hemopoietic cells and maintained this process for a definite period of time automatically.

• Authors: M S Gordeeva, A V Izvekova, M A Tumanian
• Journal: Biulleten' eksperimental'noi biologii i meditsiny (Biull Eksp Biol Med) Vol. 79 Issue 3 Pg. 66-8 (Mar 1975) ISSN: 0365-9615 [Print] Russia (Federation)
• Vernacular Title: Deĭstvie polisakharida iz bakteriĭ briushnogo tifa na stvolovye krovetvornye kletki
• PMID: 1125415 (Publication Type: English Abstract, Journal Article)

Chemical References

• Polysaccharides, Bacterial

Topics

• Animals
• Bone Marrow (drug effects)
• Bone Marrow Cells
• Cell Division (drug effects)
• Clone Cells
• Hematopoietic Stem Cells (drug effects)
• Hybridization, Genetic
• Mice
• Mice, Inbred C57BL
• Mice, Inbred CBA
• Polysaccharides, Bacterial (pharmacology)
• Salmonella typhi (analysis)
• Spleen (cytology)