Electrophysiologic effects and efficacy of intravenous propafenone in terminating atrioventricular reentrant tachycardia in children.

Abstract

In pediatric patients with atrioventricular reentrant tachycardia, intravenous propafenone exhibits its electrophysiologic effects in a dose-dependent manner by slowing or blocking retrograde conduction at the accessory connection. The high drug efficacy (81%) in terminating tachycardia is not dependent on patient age or retrograde conduction properties of the accessory connection.

• Authors: G Hessling, K Brockmeier, H J Ruediger, H E Ulmer
• Journal: The American journal of cardiology (Am J Cardiol) Vol. 87 Issue 6 Pg. 802-4, A9 (Mar 15 2001) ISSN: 0002-9149 [Print] United States
• PMID: 11249911 (Publication Type: Clinical Trial, Journal Article)

Chemical References

• Anti-Arrhythmia Agents
• Propafenone

Topics

• Adolescent
• Age Factors
• Anti-Arrhythmia Agents (administration & dosage)
• Child
• Child, Preschool
• Dose-Response Relationship, Drug
• Electrocardiography
• Electrophysiologic Techniques, Cardiac
• Female
• Heart Conduction System (physiopathology)
• Humans
• Infant
• Infant, Newborn
• Injections, Intravenous
• Linear Models
• Male
• Propafenone (administration & dosage)
• Tachycardia, Atrioventricular Nodal Reentry (drug therapy, physiopathology)