[Delayed drug-induced hepatic injury. Evoking the role of amoxicillin-clavulinic acid combination].

Abstract

Although infrequent, hepatitis associated with amoxicillin and clavulanic acid combination is probably underestimated. Except for cases with few symptoms, a time interval between stopping treatment and the first manifestations (jaundice in most cases), sometimes of several weeks, may hinder diagnosis. We report 9 patients who exhibited this characteristic. The delay between stopping treatment and the onset of hepatitis varied from 13 days to 6 weeks after stopping the drug. Other causes of jaundice were excluded. Male sex, advancing age, or prolonged treatment (more than 10 days) may increase the risk. Complete recovery occurs within 1 to 4 months after discontinuation of treatment. The mechanism is unclear. Clinical and biological signs of hypersensitivity may suggest an immunoallergic reaction.

• Authors: J Y Mari, C Guy, M N Beyens, M Ollagnier
• Journal: Therapie (Therapie) 2000 Nov-Dec Vol. 55 Issue 6 Pg. 699-704 ISSN: 0040-5957 [Print] France
• Vernacular Title: Hépatite médicamenteuse d'apparition retardée. Evoquer le rôle de l'association amoxicilline-acide clavulanique.
• PMID: 11234465 (Publication Type: Journal Article)

Chemical References

• Anti-Bacterial Agents
• Amoxicillin-Potassium Clavulanate Combination

Topics

• Aged
• Aged, 80 and over
• Amoxicillin-Potassium Clavulanate Combination (adverse effects)
• Anti-Bacterial Agents (adverse effects)
• Chemical and Drug Induced Liver Injury (etiology)
• Drug Therapy, Combination (adverse effects)
• Female
• Humans
• Male
• Middle Aged
• Risk Factors
• Time Factors