Clavulanic Acid (Potassium Clavulanate)

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862 relevant articles (153 outcomes, 178 trials/studies) found for this Drug

Description: Clavulanic acid and its salts and esters. The acid is a suicide inhibitor of bacterial beta-lactamase enzymes from Streptomyces clavuligerus. Administered alone, it has only weak antibacterial activity against most organisms, but given in combination with beta-lactam antibiotics prevents antibiotic inactivation by microbial lactamase.

Also Known As:

Potassium Clavulanate; Clavulanate; BRL-14151; Clavulanic Acid, Monopotassium Salt; Clavulanic Acid, Monosodium Salt; MM-14151; Sodium Clavulanate; Clavulanate, Potassium; Clavulanate, Sodium; 4-Oxa-1-azabicyclo(3.2.0)heptane-2-carboxylic acid, 3-(2-hydroxyethylidene)-7-oxo-, (2R-(2alpha,3Z,5alpha))

Relationship Network

Drug Context: Research Results

Organic Chemicals: 40

Amoxicillin-Potassium Clavulanate Combination: 678

Polycyclic Compounds: 58

Bridged Compounds: 2

Bicyclo Compounds

Heterocyclic Bicyclo Compounds

Amoxicillin-Potassium Clavulanate Combination: 678

Experts

1.	Wynne, Brian: 5 articles (06/2005 - 10/2002)
2.	Arguedas, Adriano: 4 articles (06/2008 - 10/2003)
3.	File, Thomas M: 4 articles (12/2007 - 10/2002)
4.	Jacobs, Michael R: 4 articles (06/2005 - 10/2002)
5.	Song, James: 3 articles (08/2007 - 11/2005)
6.	Busman, Todd A: 3 articles (09/2006 - 09/2004)
7.	Block, Stan L: 3 articles (09/2006 - 10/2003)
8.	Brook, Itzhak: 3 articles (11/2005 - 04/2004)
9.	Lipsky, Benjamin A: 2 articles (08/2007 - 01/2004)
10.	Giordano, Philip: 2 articles (08/2007 - 11/2005)

Related Diseases

1.	Infection 10/01/2000 - "Lymphocutaneous Nocardia brasiliensis infection: a pediatric case cured with amoxicilin/clavulanate." 11/01/1996 - "In younger children, Haemophilus influenzae infections are frequent and clavulanic acid must be associated" 01/01/1995 - "Comparative study of ofloxacin+amoxicillin-clavulanic acid versus doxycycline+amoxicillin-clavulanic acid combination in the treatment of pelvic Chlamydia trachomatis infections]" 05/01/1991 - "The majority of the animals treated with clavulanic acid alone (20 mg/kg) survived the infection" 05/01/1989 - "The inhibitory effect of clavulanic acid for the extended broad-spectrum betalactamases shows that such an association could be probably chosen as well for treatment urinary infection." Order ALL the reference details at left...
2.	Otitis Media 09/01/2001 - "Bacteriologic and clinical efficacy of high dose amoxicillin/clavulanate in children with acute otitis media." 02/01/2001 - "BACKGROUND: The recommendation of the Drug-Resistant Streptococcus pneumoniae Therapeutic Working Group that high-dose amoxicillin, with or without clavulanate, be used to treat acute otitis media (AOM) addressed concerns about the efficacy of existing therapies against drug-resistant S" 02/01/2000 - "amoxycillin/clavulanate is an effective treatment for pediatric acute otitis media and demonstrates that the b.d" 05/01/1997 - "Efficacy of twice-daily dosing of amoxycillin/clavulanate in acute otitis media in children." 10/01/1996 - "Efficacy of amoxicillin/clavulanate for acute otitis media: relation to Streptococcus pneumoniae susceptibility." Order ALL the reference details at left...
3.	Respiratory Tract Infections (Respiratory Tract Infection) 01/01/1981 - "Clavulanic acid and respiratory infection." 04/01/2004 - "Based on these results, this new amoxicillin/clavulanate formulation should be highly effective in treating respiratory tract infections due to drug-resistant S" 01/01/2004 - "These factors have contributed to the high bacteriological and clinical efficacy of amoxicillin/clavulanate in respiratory tract infection over more than 20 years" 01/01/1999 - "Efficacy of high-dose amoxicillin-clavulanate against experimental respiratory tract infections caused by strains of Streptococcus pneumoniae." 07/01/1999 - "In conclusion, amoxycillin/clavulanate 875/125 mg twice daily is as effective as amoxycillin/clavulanate 500/125 mg three times daily for the treatment of community-acquired lower respiratory tract infections and could improve patient compliance." Order ALL the reference details at left...
4.	Pneumonia (Pneumonitis) 04/01/2004 - "In line with PK/PD predictions, simulation of human pharmacokinetics in in-vitro kinetic models and in a rat model of pneumonia, amoxicillin/clavulanate 2000/125 mg twice daily was highly effective against S" 06/01/2008 - "Regardless of the exact underlying mechanism(s) of resistance, amoxycillin-clavulanate was effective in the experimental murine model in the treatment of pneumonia caused by AmpC-non-hyperproducing strains of E" 09/01/2004 - "Amoxicillin-clavulanate 2,000/125 mg twice daily was shown to be as clinically effective as amoxicillin-clavulanate 875/125 mg twice daily for 7 days in the treatment of adult patients with community-acquired pneumonia, without a noted increase in the reported rate of adverse events." 11/29/1985 - "The combination of ticarcillin and clavulanic acid is safe and effective therapy for pneumonia in anatomically compromised hosts." 06/01/2008 - "The aim of the present study was to evaluate the in-vivo efficacy of amoxycillin-clavulanate in the treatment of an experimental model of pneumonia, using two clonally related isolates (with identical repetitive extragenic palindromic sequence (REP)-PCR patterns) of AmpC-non-hyperproducing and OmpF-lacking E" Order ALL the reference details at left...
5.	Urinary Tract Infections (Urinary Tract Infection) 09/01/1983 - "The good clinical efficacy of BRL 25000 in such urinary tract infections was probably due to the fact that the urinary concentration of clavulanic acid was higher than its minimal inhibitory concentrations for these strains." 03/22/1980 - "Microbiological, pharmacological, and clinical studies show that clavulanic acid in combination with amoxycillin is effective and safe in the treatment of urinary-tract infection caused by amoxycillin-resistant bacteria." 03/01/1984 - "The pharmacokinetics and clinical efficacy of amoxycillin combined with clavulanic acid in the treatment of 32 children with urinary tract infection were studied" 08/01/1991 - "Comparison of single-dose administration and three-day course of amoxicillin with those of clavulanic acid for treatment of uncomplicated urinary tract infection in women." 05/01/1989 - "Experiments have been carried out with an association of amoxicillin and clavulanic acid for the long-term treatment of recurrent urinary tract infections" Order ALL the reference details at left...

Related Drugs and Biologics

1.	Amoxicillin (Wymox)
2.	Ticarcillin (Tarcil)
3.	Amoxicillin-Potassium Clavulanate Combination (Co-amoxiclav)
4.	beta-Lactamases (beta-Lactamase)
5.	Penicillins (Penicillin)
6.	Gentamicins (Gentamicin)
7.	cefuroxime axetil (Ceftin)
8.	Clindamycin (Cleocin)
9.	Ceftriaxone (Ceftriaxon)
10.	Azithromycin (Zithromax)

Related Therapies and Procedures

1.	Aftercare (After-Treatment)
2.	Drug Therapy (Chemotherapy)
3.	Day Care (Partial Hospitalization)
4.	Tonsillectomy
5.	Cesarean Section (Caesarean Section)

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