[Activity of cytoplasmic proteinases from rat liver in Heren's carcinoma during tumor growth and treatment with medicinal herbs].

Abstract

The dynamics of the acid and neutral proteinases general enzymes activity change in the hepatocytes postnuclear fraction in the rats suffering from the Heren's carcinoma was investigated. It was determined that in the tumor development of the enzyme activity level of both the acid and neutral proteinases increased 2,6-fold. The natural preparation of the herbs (Calendula officinalis L., Echinacea purpurea L., Scorzonera humilis L., Aconitum moldavicum Hacq.) normalizes both the activity of the investigated enzymes and coefficients of the liver weights of the sick animals. The chemical medicinal preparation 5,6-benzcumarine-5-uracil normalizes the activity of the neutral cytoplasmatic proteinases and reduces the level of the proteolytic activity of the acid enzymes in comparison with the control group of the animals as well as increases of the liver weight coefficients.

• Authors: M M Marchenko, H P Kopyl'chuk, O V Hrygor'ieva
• Journal: Ukrains'kyi biokhimichnyi zhurnal (1999 ) (Ukr Biokhim Zh (1999)) 2000 May-Jun Vol. 72 Issue 3 Pg. 91-4 Ukraine
• Vernacular Title: Aktivnist' tsytoplazmatychnykh proteïnaz pechinky shchuriv iz kartsynomoiu herena u protsesi rostu pukhlyn za diï na nykh likuval;nykh zasobiv.
• PMID: 11200483 (Publication Type: English Abstract, Journal Article)

Chemical References

• Plant Extracts

Topics

• Animals
• Cytoplasm (enzymology)
• Hydrolysis
• Liver (enzymology, pathology)
• Liver Neoplasms (enzymology)
• Organ Size (drug effects)
• Plant Extracts (pharmacology)
• Plants, Medicinal (chemistry)
• Rats