Abstract |
The aim was to evaluate 24 hr urine catecholamine, HMMA and HVA excretion in relation to ploidy in phaeochromocytoma. Data from five diploid and nine tetraploid tumours showed a significant reduction in urine noradrenaline (p = 0.02) and HMMA (p = 0.03) in diploid tumours but no difference in adrenaline, dopamine and HVA excretion using the Mann-Whitney U test. None of the patients showed recurrence after a mean of 5.7 years of follow up. A review of published ploidy studies in phaeochromocytoma shows that malignancy is more than six times more common in non-diploid tumours but diploidy does not equate with benignity. No biochemical marker is a reliable index of malignancy. All patients should undergo lifetime review for recurrence.
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Authors | W P Tormey, R J Fitzgerald, G Thomas, E W Kay, M B Leader |
Journal | International journal of clinical practice
(Int J Clin Pract)
Vol. 54
Issue 8
Pg. 520-3
(Oct 2000)
ISSN: 1368-5031 [Print] India |
PMID | 11198730
(Publication Type: Journal Article, Review)
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Chemical References |
- Biomarkers, Tumor
- Catecholamines
- Lactates
- atrolactic acid
- Homovanillic Acid
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Topics |
- Adrenal Gland Neoplasms
(genetics, metabolism)
- Biomarkers, Tumor
(urine)
- Catecholamines
(urine)
- Chromatography, High Pressure Liquid
- Flow Cytometry
- Homovanillic Acid
(urine)
- Humans
- Lactates
(urine)
- Neoplasm Recurrence, Local
(genetics, metabolism)
- Pheochromocytoma
(genetics, metabolism)
- Ploidies
- Predictive Value of Tests
- Statistics, Nonparametric
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