Joint scintigraphy in rabbits with 99mtc-N-[3-(triethylammonio)propyl]-15ane-N5, a new radiodiagnostic agent for articular cartilage imaging.

Abstract

UNLABELLED:

The aim of this study was to investigate joint scintigraphy in rabbits with 99mTc-N-[3-(triethylammonio)propyl]-15ane-N5 (NTP 15-5), a new radiopharmaceutical that specifically localizes in cartilaginous tissues.

METHODS:

Scans obtained after intravenous injection of the 99mTc-labeled compound in normal and arthropathy-induced rabbits were compared with those of the bone-imaging agent 99mTc-methylene diphosphonate (99mTc-MDP).

RESULTS:

The radioactive uptake of 99mTc-NTP 15-5 was detected in cartilaginous tissues 5 min after injection and was stable for 2 h. The uptake intensity was related to age and joint disease severity, and cartilage alterations not revealed by radiography induced a significant decrease of radiotracer uptake. On the other hand, imaging performed with 99mTc-MDP did not reveal the early changes in arthrosis but was more specific for bone remodeling in advanced stages of diseases or in inflammatory processes.

CONCLUSION:

Our results indicate that 99mTc-NTP 15-5 could be a good tracer for human arthrosic and arthritic cartilage detection, especially for the early diagnosis of joint diseases.

• Authors: M Ollier, J C Maurizis, C Nicolas, J Bonafous, M de Latour, A Veyre, J C Madelmont
• Journal: Journal of nuclear medicine : official publication, Society of Nuclear Medicine (J Nucl Med) Vol. 42 Issue 1 Pg. 141-5 (Jan 2001) ISSN: 0161-5505 [Print] United States
• PMID: 11197964 (Publication Type: Comparative Study, Journal Article)

Chemical References

• Heterocyclic Compounds, 1-Ring
• N-(triethylammonium)-3-propyl(15)ane-N5
• Quaternary Ammonium Compounds
• Radiopharmaceuticals
• Technetium
• Zymosan
• Technetium Tc 99m Medronate

Topics

• Animals
• Arthritis (chemically induced, diagnostic imaging)
• Cartilage, Articular (diagnostic imaging)
• Heterocyclic Compounds, 1-Ring
• Joints (diagnostic imaging)
• Quaternary Ammonium Compounds
• Rabbits
• Radionuclide Imaging
• Radiopharmaceuticals
• Technetium
• Technetium Tc 99m Medronate
• Zymosan