Effects of a dual L/N-type Ca(2+) channel blocker cilnidipine on neurally mediated chronotropic response in anesthetized dogs.

Abstract

We investigated the effects of an L-type and N-type Ca(2+) channel blocker, cilnidipine, on neurally mediated chronotropic responses to clarify the anti-autonomic profile of cilnidipine in anesthetized dogs. Pretreatment with cilnidipine (0.3, 1.0 and 3.0 microg/kg, i.v.), which decreased mean blood pressure by 5 to 31 mm Hg, inhibited the changes in heart rate and plasma norepinephrine concentration induced by bilateral carotid artery occlusion, whereas it had no effect on vagal nerve stimulation-induced bradycardia. These results suggest that antihypertensive and antisympathetic doses of cilnidipine fail to influence chronotropic responses mediated by parasympathetic nerve activation in the in vivo canine heart.

• Authors: T Konda, A Takahara, K Maeda, H Dohmoto, R Yoshimoto
• Journal: European journal of pharmacology (Eur J Pharmacol) Vol. 413 Issue 1 Pg. 117-20 (Feb 09 2001) ISSN: 0014-2999 [Print] Netherlands
• PMID: 11173070 (Publication Type: Journal Article)

Chemical References

• Antihypertensive Agents
• Calcium Channel Blockers
• Calcium Channels, L-Type
• Calcium Channels, N-Type
• Dihydropyridines
• cilnidipine
• Norepinephrine

Topics

• Anesthesia, General
• Animals
• Antihypertensive Agents (pharmacology, therapeutic use)
• Blood Pressure (drug effects)
• Bradycardia (blood, drug therapy)
• Calcium Channel Blockers (pharmacology, therapeutic use)
• Calcium Channels, L-Type (metabolism)
• Calcium Channels, N-Type (metabolism)
• Carotid Arteries (physiopathology)
• Coronary Disease (physiopathology)
• Dihydropyridines (pharmacology, therapeutic use)
• Dogs
• Electric Stimulation
• Heart (drug effects)
• Heart Rate (drug effects)
• Male
• Norepinephrine (blood)
• Vagus Nerve (physiology)